Low power 400 MHz FSK transmitter and low-IF reciever for bio-telemetry application were designed, fabricated and successfully measured in 180 nm UMC process. Portable, low power battery operated prototypes were also developed with these custom designed FSK transmitter and receiver ICs. These are the first reported indigenous low power bio-telemetry ICs in India for biosignal communication in proprietary 400 MHz ISM band meeting the FCC recommendations.