“Design of delta sigma-modulators for multichannel biomedical applications introduces challenges with high density and very low power consumption. While possible solutions in the form of VCO based and passive integrator based delta sigma-modulators have been reported, these modulators suffer from limited resolution. Hybrid delta sigma-modulators provide an excellent trade-off between area, power, and achievable resolution compared to the counterpart active and passive integrator delta sigma-modulators. This work explores hybrid CTDSM architectures for multichannel biomedical applications, operating with a single clock-phase. To alleviate the high power consumption of the active integrators in the CTDSM, an auxiliary DAC based and a passive RC front-end based hybrid CTDSMs are proposed. Through a detailed analysis and performance comparison, we demonstrate that the two proposed hybrid architectures exhibit the classical area-power trade-off for a target resolution. We demonstrate the designs in standard 180nm mixed-mode CMOS technology for biomedical bandwidth. Measurement results show that the auxiliary DAC and the PRCFE based hybrid CTDSMs achieve an SNDR&DR of 65.18&68.3 dB and 66.85&71.1 dB while consuming 845nW and 730nW power and achieving an FoM of 28.48 fJ/conv and 20.3 fJ/conv., respectively, ideal for multichannel biomedical applications.”